p53 tumour suppressor gene polymorphism is associated with recurrent implantation failure

Recurrent pregnancy failure is associated with a polymorphism in the p53 tumour suppressor gene.

BACKGROUND The p53 tumour suppressor gene is a well-known factor regulating apoptosis in a wide variety of cells and tissues. Alterations in the p53 gene are among the most common genetic changes in human cancers. In addition, recent data provide evidence that p53 plays a critical role in mediating pregnancy by regulating steroid hormone activation. In idiopathic recurrent miscarriages (IRM), c...

P-195: The Relationship between PAI-1 Polymorphism with Recurrent Implantation Failure (RIF)

Background: RIF is the most common cause of unsuccessful pregnancy after IVF. Among the various causes of RIF, the role of maternal genetic factors is of great significance. PAI-1 polymorphism is one of the notable polymorphisms in this field. In this study, the relationship between this polymorphism and the recurrent spontaneous abortions and infertility in different populations has been inves...

Recurrent Implantation Failure Is More Frequently Seen in Female Patients with Poor Prognosis

I-24: Recurrent Implantation Failure

Recurrent implantation failure (RIF) has many definitions, but usually authors consider RIF, the failure to achieve a pregnancy fallowing 2-6 IVF cycles in which more than 10 high grade embryos were transferred to the uterus. There are a lot of causes for RIF but two main causes of that are related to embryo and endometrium. Chromosomal abnormalities, zona hardening and problems in culture medi...

p53 tumour suppressor gene expression in pancreatic neuroendocrine tumour cells.

Neuroendocrine pancreatic tumours grow slower and metastasise later than ductal and acinar carcinomas. The expression of the p53 tumour suppressor gene in pancreatic neuroendocrine tumour cells is unknown. Pancreatic neuroendocrine cell lines (n = 5) and human tumour tissues (n = 19) were studied for changed p53 coding sequence, transcription, and translation. Proliferative activity of tumour c...